Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
14585902
TITLE
Dizygotic twinning is not associated with methylenetetrahydrofolate reductase haplotypes.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Folate metabolism is critical to embryonic development, influencing neural tube defects (NTD) and recurrent early pregnancy loss. Polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR) have been associated with dizygotic (DZ) twinning through pregnancy loss.
METHODS NlmCategory: METHODS
The C677T and A1298C polymorphisms in MTHFR were genotyped in 258 Australasian families (1016 individuals) and 118 Dutch families (462 individuals) of mothers of DZ twins and a population sample of 462 adolescent twin families (1861 individuals). Haplotypes were constructed from the alleles, and transmission of the MTHFR haplotypes to mothers of DZ twins and from parents to twins in the adolescent twin families analysed.
RESULTS NlmCategory: RESULTS
The C677T and A1298C were common in all three populations (frequencies > 0.29). There was strong linkage disequilibrium (D' = 1) between the variants, showing that specific combinations of alleles (haplotypes) were transmitted together. Three haplotypes accounted for nearly all the variation. There was no evidence of any association between MTHFR genotype and twinning in mothers of twins, or of the loss of specific MTHFR genotypes during twin pregnancies.
CONCLUSIONS NlmCategory: CONCLUSIONS
It is concluded that variation in twinning frequency is not associated with MTHFR genotype.
DATE PUBLISHED
2003 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2003/10/31 05:00
medline 2004/06/25 05:00
entrez 2003/10/31 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Montgomery GW Montgomery Grant W GW Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia. grantM@qimr.edu.au
Zhao ZZ Zhao Zhen Zhen ZZ
Morley KI Morley Katherine I KI
Marsh AJ Marsh Anna J AJ
Boomsma DI Boomsma Dorret I DI
Martin NG Martin Nicholas G NG
Duffy DL Duffy David L DL
INVESTIGATORS
JOURNAL
VOLUME: 18
ISSUE: 11
TITLE: Human reproduction (Oxford, England)
ISOABBREVIATION: Hum. Reprod.
YEAR: 2003
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0268-1161
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Hum Reprod
COUNTRY: England
ISSNLINKING: 0268-1161
NLMUNIQUEID: 8701199
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
HD042157 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adenine
Adolescent
Alleles
Asian Continental Ancestry Group genetics
Australia genetics
Cytosine genetics
Gene Frequency genetics
Genotype genetics
Haplotypes genetics
Humans genetics
Linkage Disequilibrium genetics
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Netherlands genetics
Thymine genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
8J337D1HZY Cytosine
EC 1.5.1.20 Methylenetetrahydrofolate Reductase (NADPH2)
JAC85A2161 Adenine
QR26YLT7LT Thymine
OTHER ID's