Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
14511440
TITLE
Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels.
ABSTRACT
Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.
DATE PUBLISHED
2003 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2003/09/27 05:00
medline 2005/02/03 09:00
entrez 2003/09/27 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Beekman M Beekman Marian M Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. M.Beekman@lumc.nl.
Heijmans BT Heijmans Bastiaan T BT
Martin NG Martin Nicholas G NG
Whitfield JB Whitfield John B JB
Pedersen NL Pedersen Nancy L NL
DeFaire U DeFaire Ulf U
Snieder H Snieder Harold H
Lakenberg N Lakenberg Nico N
de Knijff P de Knijff Peter P
Frants RR Frants Rune R RR
van Ommen GJ van Ommen Gert Jan B GJ
Kluft C Kluft Cornelis C
Vogler GP Vogler George P GP
Slagboom PE Slagboom P Eline PE
Boomsma DI Boomsma Dorret I DI
INVESTIGATORS
JOURNAL
VOLUME: 6
ISSUE: 4
TITLE: Twin research : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res
YEAR: 2003
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1369-0523
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res
COUNTRY: Australia
ISSNLINKING: 1369-0523
NLMUNIQUEID: 9815819
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AG04563 NIA NIH HHS United States
HL55976 NHLBI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 6
Genetic Linkage
Humans
Lipoproteins genetics
Quantitative Trait Loci genetics
Twins genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Lipoproteins
OTHER ID's