Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
11964723
TITLE
Applying statistical approaches in the dissection of genes versus environment for asthma and allergic disease.
ABSTRACT
Now that some of the genes involved in asthma and allergy have been identified, interest is turning to how genetic predisposition interacts with exposure to environmental risk factors. These questions are best answered by studies in which both genotypes and other risk factors are measured, but even simpler studies, in which family history is used as a proxy for genotype, have made suggestive findings. For example, early breast feeding may increase the risk of allergic disease in genetically susceptible children, and decrease the risk of 'sporadic' allergy. This review also addresses the overall importance of genetic causes of allergic disease in the general population.
DATE PUBLISHED
2001 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2002/04/20 10:00
medline 2002/06/14 10:01
entrez 2002/04/20 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Duffy DL Duffy D L DL Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia. davidd@qimr.edu.au
INVESTIGATORS
JOURNAL
VOLUME: 1
ISSUE: 5
TITLE: Current opinion in allergy and clinical immunology
ISOABBREVIATION: Curr Opin Allergy Clin Immunol
YEAR: 2001
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1528-4050
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Curr Opin Allergy Clin Immunol
COUNTRY: United States
ISSNLINKING: 1473-6322
NLMUNIQUEID: 100936359
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Review
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Asthma genetics
Data Interpretation, Statistical genetics
Environment genetics
Genetic Linkage genetics
Humans genetics
Hypersensitivity, Immediate genetics
Quantitative Trait, Heritable genetics
Risk Factors genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's