Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
11836304
TITLE
Genetics of serum dehydroepiandrosterone sulfate and its relationship to insulin in a population-based cohort of twin subjects.
ABSTRACT
Previous studies have shown a significant effect of insulin administration on serum dehydroepiandrosterone sulfate (DHEA-S) concentration and its metabolic rate, with evidence for the effect in men, but not in women. This could lead to differences in the sources of variation in serum DHEA-S between men and women and in its covariation with insulin concentration. This study aimed to test whether these hypotheses were supported in a sample of healthy adult twins. Serum DHEA-S (n = 2287) and plasma insulin (n = 2436) were measured in samples from adult male and female twins recruited through the Australian Twin Registry. Models of genetic and environmental sources of variation and covariation were tested against the data. DHEA-S showed substantial genetic effects in both men and women after adjustment for covariates, including sex, age, body mass index, and time since the last meal. There was no significant phenotypic or genetic correlation between DHEA-S and insulin in either men or women. Despite the experimental evidence for insulin infusion producing a reduction in serum DHEA-S and some effect of meals on the observed DHEA-S concentration, there were no associations between insulin and DHEA-S at the population level. Variations in DHEA-S are due to age, sex, obesity, and substantial polygenic genetic influences.
DATE PUBLISHED
2002 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2002/02/12 10:00
medline 2002/03/02 10:01
entrez 2002/02/12 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Nestler JE Nestler John E JE Division of Endocrinology, Department of Medicine, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23398, USA.
Whitfield JB Whitfield John B JB
Williams TY Williams Terre Y TY
Zhu G Zhu Gu G
Condon J Condon Juliann J
Kirk KM Kirk Katherine M KM
Heath AC Heath Andrew C AC
Montgomery GW Montgomery Grant W GW
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 87
ISSUE: 2
TITLE: The Journal of clinical endocrinology and metabolism
ISOABBREVIATION: J. Clin. Endocrinol. Metab.
YEAR: 2002
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0021-972X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: J Clin Endocrinol Metab
COUNTRY: United States
ISSNLINKING: 0021-972X
NLMUNIQUEID: 0375362
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA-07535 NIAAA NIH HHS United States
AA-07728 NIAAA NIH HHS United States
R01-HD-35629 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aging blood
Body Mass Index blood
Cohort Studies blood
Dehydroepiandrosterone Sulfate blood
Environment blood
Female blood
Genetic Variation blood
Humans blood
Insulin blood
Male blood
Middle Aged blood
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Insulin
57B09Q7FJR Dehydroepiandrosterone Sulfate
OTHER ID's