Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
11803517
TITLE
Genetic covariation of neuroticism with monoamine oxidase activity and smoking.
ABSTRACT
Variation in the personality trait of neuroticism is known to be affected by genetic influences, but despite a number of association studies, the genes involved have not yet been characterized. In a recent study of platelet monoamine oxidase in 1,551 twin subjects, we found a significant association between monoamine oxidase activity and scores on the Eysenck Personality Questionnaire neuroticism scale. Further analyses presented here indicate that both neuroticism and monoamine oxidase activity are associated with variation in smoking habits, and that adjusting for the effect of smoking strengthens the association between MAO and neuroticism. Analysis of the genetic and environmental sources of covariation between neuroticism, smoking, and monoamine oxidase activity show that approximately 8% of the genetic variance in neuroticism is due to the same additive genetic effects that contribute to variation in monoamine oxidase activity, suggesting that variation in neuroticism is associated in part with aspects of serotonin metabolism.
Copyright 2001 Wiley-Liss, Inc.
DATE PUBLISHED
2001 Dec 8
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2002/01/23 10:00
medline 2002/03/07 10:01
entrez 2002/01/23 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kirk KM Kirk K M KM Department of Psychiatry, University of Queensland, Brisbane, Australia. kathe@qimr.edu.au
Whitfield JB Whitfield J B JB
Pang D Pang D D
Heath AC Heath A C AC
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 105
ISSUE: 8
TITLE: American journal of medical genetics
ISOABBREVIATION: Am. J. Med. Genet.
YEAR: 2001
MONTH: Dec
DAY: 8
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0148-7299
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet
COUNTRY: UNITED STATES
ISSNLINKING: 0148-7299
NLMUNIQUEID: 7708900
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Female
Genetic Variation
Humans
Male
Models, Biological
Monoamine Oxidase metabolism
Multivariate Analysis metabolism
Neurotic Disorders psychology
Personality Inventory statistics & numerical data
Phenotype statistics & numerical data
Smoking statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
EC 1.4.3.4 Monoamine Oxidase
OTHER ID's