Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
11665331
TITLE
An integrative approach for studying the etiology of alcoholism and other addictions.
ABSTRACT
Studies of alcoholism etiology often focus on genetic or psychosocial approaches, but not both. Greater understanding of the etiology of alcohol, tobacco and other addictions will come from integration of these research traditions. A research approach is outlined to test three models for the etiology of addictions--behavioral undercontrol, pharmacologic vulnerability, negative affect regulation--addressing key questions including (i) mediators of genetic effects, (ii) genotype-environment correlation effects, (iii) genotype x environment interaction effects, (iv) the developmental unfolding of genetic and environmental effects, (v) subtyping including identification of distinct trajectories of substance involvement, (vi) identification of individual genes that contribute to risk, and (vii) the consequences of excessive use. By using coordinated research designs, including prospective assessment of adolescent twins and their siblings and parents; of adult substance dependent and control twins and their MZ and DZ cotwins, the spouses of these pairs, and their adolescent offspring; and of regular families; by selecting for gene-mapping approaches sibships screened for extreme concordance or discordance on quantitative indices of substance use; and by using experimental (drug challenge) as well as survey approaches, a number of key questions concerning addiction etiology can be addressed. We discuss complementary strengths and weaknesses of different sampling strategies, as well as methods to implement such an integrated approach illustrated for the study of alcoholism etiology. A coordinated program of twin and family studies will allow a comprehensive dissection of the interplay of genetic and environmental risk-factors in the etiology of alcoholism and other addictions.
DATE PUBLISHED
2001 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2001/10/23 10:00
medline 2002/01/05 10:01
entrez 2001/10/23 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jacob T Jacob T T Palo Alto Veterans Administration, Palo Alto, California, USA.
Sher KJ Sher K J KJ
Bucholz KK Bucholz K K KK
True WT True W T WT
Sirevaag EJ Sirevaag E J EJ
Rohrbaugh J Rohrbaugh J J
Nelson E Nelson E E
Neuman RJ Neuman R J RJ
Todd RD Todd R D RD
Slutske WS Slutske W S WS
Whitfield JB Whitfield J B JB
Kirk KM Kirk K M KM
Martin NG Martin N G NG
Madden PA Madden P A PA
Heath AC Heath A C AC
INVESTIGATORS
JOURNAL
VOLUME: 4
ISSUE: 2
TITLE: Twin research : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res
YEAR: 2001
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1369-0523
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res
COUNTRY: Australia
ISSNLINKING: 1369-0523
NLMUNIQUEID: 9815819
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, U.S. Gov't, P.H.S.
Review
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
P01-CA-75581 NCI NIH HHS United States
P50-AA11998 NIAAA NIH HHS United States
R01-AA09022 NIAAA NIH HHS United States
R01-AA10248 NIAAA NIH HHS United States
R01-AA11667 NIAAA NIH HHS United States
R01-AA11822 NIAAA NIH HHS United States
R01-DA12540 NIDA NIH HHS United States
R01-DA12854 NIDA NIH HHS United States
R37-AA07728 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alcoholism psychology
Behavior, Addictive psychology
Diseases in Twins etiology
Family etiology
Female etiology
Humans etiology
Male etiology
Models, Genetic etiology
Models, Psychological etiology
Parent-Child Relations etiology
Research Design etiology
Risk Factors etiology
Sampling Studies etiology
Spouses etiology
Twin Studies as Topic methods
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's