Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
11505030
TITLE
Effects of alcohol consumption on indices of iron stores and of iron stores on alcohol intake markers.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Alcohol increases body iron stores. Alcohol and iron may increase oxidative stress and the risk of alcohol-related liver disease. The relationship between low or "safe" levels of alcohol use and indices of body iron stores, and the factors that affect the alcohol-iron relationship, have not been fully characterized. Other aspects of the biological response to alcohol use have been reported to depend on iron status.
METHODS NlmCategory: METHODS
We have measured serum iron, transferrin, and ferritin as indices of iron stores in 3375 adult twin subjects recruited through the Australian Twin Registry. Information on alcohol use and dependence and smoking was obtained from questionnaires and interviews.
RESULTS NlmCategory: RESULTS
Serum iron and ferritin increased progressively across classes of alcohol intake. The effects of beer consumption were greater than those of wine or spirits. Ferritin concentration was significantly higher in subjects who had ever been alcohol dependent. There was no evidence of interactions between HFE genotype or body mass index and alcohol. Alcohol intake-adjusted carbohydrate-deficient transferrin was increased in women in the lowest quartile of ferritin results, whereas adjusted gamma-glutamyltransferase, aspartate aminotransferase, and alanine aminotransferase values were increased in subjects with high ferritin.
CONCLUSIONS NlmCategory: CONCLUSIONS
Alcohol intake at low level increases ferritin and, by inference, body iron stores. This may be either beneficial or harmful, depending on circumstances. The response of biological markers of alcohol intake can be affected by body iron stores; this has implications for test sensitivity and specificity and for variation in biological responses to alcohol use.
DATE PUBLISHED
2001 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2001/08/16 10:00
medline 2001/09/14 10:01
entrez 2001/08/16 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield J B JB Department of Clinical Biochemistry, Royal Prince Alfred Hospital, and University of Sydney, Sydney, Australia. johnwit@bioc.rpa.cs.nsw.gov.au
Zhu G Zhu G G
Heath AC Heath A C AC
Powell And LW Powell And L W LW
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 25
ISSUE: 7
TITLE: Alcoholism, clinical and experimental research
ISOABBREVIATION: Alcohol. Clin. Exp. Res.
YEAR: 2001
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0145-6008
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Alcohol Clin Exp Res
COUNTRY: England
ISSNLINKING: 0145-6008
NLMUNIQUEID: 7707242
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alanine Transaminase blood
Alcohol Drinking blood
Aspartate Aminotransferases blood
Biological Markers blood
Body Mass Index blood
Central Nervous System Depressants pharmacology
Ethanol pharmacology
Female pharmacology
Genotype pharmacology
Humans pharmacology
Iron metabolism
Male metabolism
Polymorphism, Genetic metabolism
Sex Characteristics metabolism
Smoking metabolism
Transferrin metabolism
gamma-Glutamyltransferase metabolism
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Biological Markers
0 Central Nervous System Depressants
0 Transferrin
0 carbohydrate-deficient transferrin
3K9958V90M Ethanol
E1UOL152H7 Iron
EC 2.3.2.2 gamma-Glutamyltransferase
EC 2.6.1.1 Aspartate Aminotransferases
EC 2.6.1.2 Alanine Transaminase
OTHER ID's