Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
11343301
TITLE
Human twinning is not linked to the region of chromosome 4 syntenic with the sheep twinning gene FecB.
ABSTRACT
The tendency to dizygotic (DZ) twinning is inherited in both humans and sheep, and a fecundity gene in sheep (FecB) maps to sheep chromosome 6, syntenic with human 4q21-25. Our aim was to see whether a gene predisposing to human DZ twinning mapped to this region. DNA was collected from 169 pairs and 17 sets of 3 sisters (trios) from Australia and New Zealand who had each had spontaneous DZ twins, mostly before the age of 35, and from a replication sample of 111 families (92 affected sister pairs) from The Netherlands. Exclusion mapping was carried out after typing 26 markers on chromosome 4, of which 8 spanned the region likely to contain the human homologue of the sheep FecB gene. We used nonparametric affected sib pair methods for linkage analysis [ASPEX 2.2, Hinds and Risch, 1999]. Complete exclusion of linkage (lod < -2) of a gene conferring a relative risk for sibs as low as 1.5 (lambda(s) > 1.5) was obtained for all but the p terminus region on chromosome 4. Exclusion in the syntenic region was stronger, down to lambda(s) = 1.3. We concluded that if there is a gene influencing DZ twinning on chromosome 4, its effect must be minor.
Copyright 2001 Wiley-Liss, Inc.
DATE PUBLISHED
2001 May 1
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2001/05/09 10:00
medline 2001/09/14 10:01
entrez 2001/05/09 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Duffy DL Duffy D L DL Genetic Epidemiology Unit, Queensland Institute of Medical Research and Joint Genetics Program, The University of Queensland, Brisbane, Queensland, Australia. davidD@qimr.edu.au
Montgomery GW Montgomery G W GW
Hall J Hall J J
Mayne C Mayne C C
Healey SC Healey S C SC
Brown J Brown J J
Boomsma DI Boomsma D I DI
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 100
ISSUE: 3
TITLE: American journal of medical genetics
ISOABBREVIATION: Am. J. Med. Genet.
YEAR: 2001
MONTH: May
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0148-7299
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Med Genet
COUNTRY: UNITED STATES
ISSNLINKING: 0148-7299
NLMUNIQUEID: 7708900
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Animals
Chromosome Mapping
Chromosomes, Human, Pair 4
DNA genetics
Female genetics
Genetic Linkage genetics
Genetic Markers genetics
Genome genetics
Humans genetics
Sheep genetics
Species Specificity genetics
Twins, Dizygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
9007-49-2 DNA
OTHER ID's