Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
11315223
TITLE
Towards a molecular epidemiology of alcohol dependence: analysing the interplay of genetic and environmental risk factors.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Progress in identifying genetic factors protective against alcohol dependence (AlcD) requires a paradigm shift in psychiatric epidemiology.
AIMS NlmCategory: OBJECTIVE
To integrate analysis of research into the genetics of alcoholism.
METHOD NlmCategory: METHODS
Data from prospective questionnaire and interview surveys of the Australian twin panel, and from a subsample who underwent alcohol challenge, were analysed.
RESULTS NlmCategory: RESULTS
In men, effects of alcohol dehydrogenase ADH2*1/*2 genotype or high alcohol sensitivity (risk-decreasing), and of history of childhood conduct disorder, or having monozygotic co-twin or twin sister with AlcD (risk-increasing) were significant and comparable in magnitude. Religious affiliation (Anglican versus other) was associated with the ADH2 genotype, but did not explain the associations with AlcD symptoms. No protective effect of the ADH2*1/*2 genotype was observed in women.
CONCLUSIONS NlmCategory: CONCLUSIONS
The early onset and strong familial aggregation of AlcD, and opportunity for within-family tests of genetic association to avoid confounding effects, make epidemiological family studies of adolescents and young adults and their families a priority.
DATE PUBLISHED
2001 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2001/04/24 10:00
medline 2001/06/02 10:01
entrez 2001/04/24 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Heath AC Heath A C AC Missouri Alcoholism Research Center, Washington University, St Louis, Missouri, USA. andrew@matlock.wustl.edu
Whitfield JB Whitfield J B JB
Madden PA Madden P A PA
Bucholz KK Bucholz K K KK
Dinwiddie SH Dinwiddie S H SH
Slutske WS Slutske W S WS
Bierut LJ Bierut L J LJ
Statham DB Statham D B DB
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 40
ISSUE:
TITLE: The British journal of psychiatry. Supplement
ISOABBREVIATION: Br J Psychiatry Suppl
YEAR: 2001
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0960-5371
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Br J Psychiatry Suppl
COUNTRY: England
ISSNLINKING: 0960-5371
NLMUNIQUEID: 9001294
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
DA00272 NIDA NIH HHS United States
DA07261 NIDA NIH HHS United States
MH14677 NIMH NIH HHS United States
MH17104 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alcohol Dehydrogenase genetics
Alcoholism genetics
Aldehyde Dehydrogenase genetics
Ethanol metabolism
Female metabolism
Genotype metabolism
Humans metabolism
Male metabolism
Molecular Epidemiology metabolism
Prospective Studies metabolism
Questionnaires metabolism
Risk Factors metabolism
Social Values metabolism
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
3K9958V90M Ethanol
EC 1.1.1.1 Alcohol Dehydrogenase
EC 1.2.1.3 Aldehyde Dehydrogenase
OTHER ID's