Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
11037324
TITLE
Genotype-environment interaction in transmission disequilibrium tests.
ABSTRACT
Transmission disequilibrium tests (TDTs) provide an approach to the detection of associations between alleles at marker loci and risk of complex disorders. The logistic regression approach to TDTs proposed by Sham and Curtis (1995) is generalized to provide separate tests of the main effects of marker loci on genetic risk and genotype-environment interaction (G x E) arising because multiple alleles differ in their sensitivity to specified environmental covariates. A modification of the same model may be used to detect the effects of genomic imprinting on the expression of susceptibility loci. In the presence of G x E, highly significant genetic effects may be present that will not produce marked twin or sibling resemblance and will not yield significant associations in conventional TDTs. However, simulation studies show how the logistic regression model can be used to detect the main effects of marker alleles and their interaction with covariates on continuous outcomes in offspring-parent trios, pairs of siblings and their parents, and monozygotic twin pairs and their parents. TDT tests with MZ with twin pairs permit the detection of alleles whose primary effects on the phenotype are mediated through the control of sensitivity to latent features of the within-family environment. It is shown that although the genotype-environment correlation caused by the environmental effects of parental alleles on offspring phenotypes can produce spurious marker-phenotype association in population studies, the outcome of TDTs is not biased thereby.
DATE PUBLISHED
2001
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2000/10/19 11:00
medline 2001/02/28 10:01
entrez 2000/10/19 11:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Eaves LJ Eaves L J LJ Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond 23298, USA.
Sullivan P Sullivan P P
INVESTIGATORS
JOURNAL
VOLUME: 42
ISSUE:
TITLE: Advances in genetics
ISOABBREVIATION: Adv. Genet.
YEAR: 2001
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0065-2660
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Adv Genet
COUNTRY: United States
ISSNLINKING: 0065-2660
NLMUNIQUEID: 0370421
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, U.S. Gov't, P.H.S.
Review
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
MH45268 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alleles
Carcinogens, Environmental adverse effects
Chromosome Mapping statistics & numerical data
Computer Simulation statistics & numerical data
Female statistics & numerical data
Gene Frequency statistics & numerical data
Genomic Imprinting genetics
Genotype genetics
Humans genetics
Linkage Disequilibrium genetics
Logistic Models genetics
Male genetics
Nuclear Family genetics
Risk Factors genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Carcinogens, Environmental
OTHER ID's