Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
10824664
TITLE
Monoamine oxidase: associations with alcohol dependence, smoking and other measures of psychopathology.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Many reports have appeared on associations between platelet monoamine oxidase (MAO) activity and susceptibility to psychiatric conditions; principally alcohol dependence but also conduct disorder, other drug use and depression. Recently, it has become apparent that MAO activity is inhibited by some component of cigarette smoke, and smokers have low platelet MAO activity. Since the prevalence of smoking is higher in many of the conditions in which MAO has been implicated, the MAO susceptibility associations may be partly, or entirely, false.
METHODS NlmCategory: METHODS
We have measured platelet MAO in 1551 subjects, recruited from the Australian NHMRC Twin Registry, who have provided information on alcohol use and dependence, smoking, conduct disorder, depression, attempted suicide, panic disorder and social phobia.
RESULTS NlmCategory: RESULTS
Current smoking reduced platelet MAO activity in a significant and dose-related manner, with no evidence of lower MAO in ex-smokers or in non-smoking subjects with co-twins who smoked. Alcohol use and lifetime DSM-III-R alcohol dependence history were not associated with MAO activity when smoking was taken into account. Depression, panic disorder and social phobia showed no significant associations with platelet MAO activity. Subjects with a history of serious attempts at suicide had low platelet MAO activity; but although the difference from controls was as great as the reduction associated with smoking it was not significant after correction for smoking effects.
CONCLUSIONS NlmCategory: CONCLUSIONS
Although synaptic MAO activity undoubtedly plays a role in psychopathology, the concept that platelet MAO activity is a direct genetic marker of vulnerability to alcohol dependence cannot be sustained.
DATE PUBLISHED
2000 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2000/05/29 09:00
medline 2000/09/02 11:01
entrez 2000/05/29 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Whitfield JB Whitfield J B JB Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
Pang D Pang D D
Bucholz KK Bucholz K K KK
Madden PA Madden P A PA
Heath AC Heath A C AC
Statham DJ Statham D J DJ
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 30
ISSUE: 2
TITLE: Psychological medicine
ISOABBREVIATION: Psychol Med
YEAR: 2000
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0033-2917
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Psychol Med
COUNTRY: England
ISSNLINKING: 0033-2917
NLMUNIQUEID: 1254142
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alcoholism psychology
Blood Platelets enzymology
Diseases in Twins genetics
Female genetics
Genetic Markers genetics
Genetic Predisposition to Disease genetics
Humans genetics
Male genetics
Mental Disorders psychology
Middle Aged psychology
Monoamine Oxidase blood
Psychiatric Status Rating Scales blood
Psychopathology blood
Smoking psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
EC 1.4.3.4 Monoamine Oxidase
OTHER ID's