Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
10797518
TITLE
Genetic analysis of the age at menopause by using estimating equations and Bayesian random effects models.
ABSTRACT
Multi-wave self-report data on age at menopause in 2182 female twin pairs (1355 monozygotic and 827 dizygotic pairs), were analysed to estimate the genetic, common and unique environmental contribution to variation in age at menopause. Two complementary approaches for analysing correlated time-to-onset twin data are considered: the generalized estimating equations (GEE) method in which one can estimate zygosity-specific dependence simultaneously with regression coefficients that describe the average population response to changing covariates; and a subject-specific Bayesian mixed model in which heterogeneity in regression parameters is explicitly modelled and the different components of variation may be estimated directly. The proportional hazards and Weibull models were utilized, as both produce natural frameworks for estimating relative risks while adjusting for simultaneous effects of other covariates. A simple Markov chain Monte Carlo method for covariate imputation of missing data was used and the actual implementation of the Bayesian model was based on Gibbs sampling using the freeware package BUGS.
Copyright 2000 John Wiley & Sons, Ltd.
DATE PUBLISHED
2000 May 15
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2000/05/08 09:00
medline 2000/07/06 11:00
entrez 2000/05/08 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Do KA Do K A KA Epidemiology and Population Health Unit, Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Queensland 4029, Australia. kim@odin.mdacc.tmc.edu
Broom BM Broom B M BM
Kuhnert P Kuhnert P P
Duffy DL Duffy D L DL
Todorov AA Todorov A A AA
Treloar SA Treloar S A SA
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 19
ISSUE: 9
TITLE: Statistics in medicine
ISOABBREVIATION: Stat Med
YEAR: 2000
MONTH: May
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0277-6715
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Stat Med
COUNTRY: England
ISSNLINKING: 0277-6715
NLMUNIQUEID: 8215016
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
A07728 PHS HHS United States
AA07535 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Aged
Aged, 80 and over
Alcohol Drinking
Australia
Bayes Theorem
Body Mass Index
Educational Status
Female
Humans
Markov Chains
Menarche
Menopause physiology
Middle Aged physiology
Models, Genetic physiology
Monte Carlo Method physiology
Parity physiology
Questionnaires physiology
Smoking physiology
Social Class physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's