Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
10547922
TITLE
A note on the power provided by sibships of sizes 2, 3, and 4 in genetic covariance modeling of a codominant QTL.
ABSTRACT
The contribution of size 3 and size 4 sibships to power in covariance structure modeling of a codominant QTL is investigated. Power calculations are based on the noncentral chi-square distribution. Sixteen sets of parameter values are considered. Results indicate that size 3 and size 4 sibships provided large increases in power over size 2 sibships. On average a size 3 (4) sibship is 3 (6 to 7) times as informative as a size 2 sibship. The increase in power does not depend on the specific effects sizes of the independent variables in the model. These findings extend results presented by Fulker and Cherny (1996) and Schork (1993). We consider the informativeness of the size 2, 3, and 4 sibships, which differ in the unique configuration of IBD sharing. Three of the 10 size 3 and 7 of the 36 size 4 sibships are particularly informative. The results presented concern random (unselective) sampling but do have implications for selective sampling.
DATE PUBLISHED
1999 May
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1999/11/05
medline 1999/11/05 00:01
entrez 1999/11/05 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Dolan CV Dolan C V CV Department of Psychology, University of Amsterdam, The Netherlands. op_dolan@macmail.psy.uva.nl
Boomsma DI Boomsma D I DI
Neale MC Neale M C MC
INVESTIGATORS
JOURNAL
VOLUME: 29
ISSUE: 3
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 1999
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-8244
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
MH01458 NIMH NIH HHS United States
RR08123 NCRR NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alleles
Analysis of Variance
Family Characteristics
Humans
Models, Genetic
Phenotype
Social Environment
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's